尸检在揭示意外神经病理学方面的作用。

Utility of autopsy in uncovering unexpected neuropathology.

机构信息

Department of Anatomic Pathology, Cleveland Clinic, OH 44195, USA.

出版信息

Ann Diagn Pathol. 2012 Oct;16(5):350-3. doi: 10.1016/j.anndiagpath.2012.02.003. Epub 2012 Apr 18.

DOI:10.1016/j.anndiagpath.2012.02.003

PMID:22520718

Abstract

Autopsy rates have declined in the last several decades for a variety of reasons. The purpose of this study is to compare autopsy neuropathologic findings from 2 periods to assess the prevalence of unexpected neuropathologic findings and unexpected neuropathologic diagnoses determined to be the major cause of death. Retrospective review of autopsies with examination of the central nervous system was performed in 2007 to 2008 (n = 289) and 1984 to 1985 (n = 328). Unexpected neuropathologic diagnoses were found at autopsy in 42.4% of cases from 1984 to 1985 vs 38.8% of cases from 2007 to 2008. The neuropathology was felt to contribute to the cause of death in 22% of cases from 1984 to 1985 vs 19.7% of cases from 2007 to 2008. Unexpected neuropathologic findings were the cause of death in 5.2% of cases from 1984 to 1985 vs 3.1% of cases from 2007 to 2008. These findings underscore the continued use of brain and spinal cord examination at autopsy despite advances in "modern" medicine.

摘要

在过去的几十年中，由于各种原因，尸检率有所下降。本研究的目的是比较两个时期的尸检神经病理学发现，以评估意外神经病理学发现的发生率和被确定为主要死亡原因的意外神经病理学诊断的发生率。对 2007 年至 2008 年（n=289）和 1984 年至 1985 年（n=328）的尸检进行了回顾性检查，检查了中枢神经系统。1984 年至 1985 年，尸检中发现意外神经病理学诊断的比例为 42.4%，而 2007 年至 2008 年为 38.8%。1984 年至 1985 年，神经病理学被认为是 22%病例死亡的原因，而 2007 年至 2008 年为 19.7%。1984 年至 1985 年，意外神经病理学发现是 5.2%病例死亡的原因，而 2007 年至 2008 年为 3.1%。这些发现强调了尽管现代医学取得了进步，但仍继续在尸检中使用大脑和脊髓检查。