[转录因子在软骨内成骨中的作用及功能调控]
[Role and function regulation of transcription factors in endochondral ossification].
作者信息
Nishimura Riko, Hata Kenji, Takashima Rikako, Yoshida Michiko
机构信息
Department of Molecular and Cellular Biochemistry Osaka University Graduate School of Dentistry, Japan.
出版信息
Clin Calcium. 2012 May;22(5):643-52.
Endochondral ossification plays critical roles in skeletal development and tissue patterning. Disruption of endochondral ossification and cartilage homeostasis results in skeletal dysplasia and cartilage diseases such as osteoarthritis. Several transcription factors regulate chondrocyte differentiation and expression of chondrogenic matrices, and consequently maintains order of endochondral ossification. In this review article, we would like to introduce recent advancement in understanding of role and functional regulation of transcription factors in endochondral ossification.
软骨内骨化在骨骼发育和组织模式形成中发挥着关键作用。软骨内骨化和软骨内环境稳定的破坏会导致骨骼发育异常和软骨疾病，如骨关节炎。几种转录因子调节软骨细胞分化和成软骨基质的表达，从而维持软骨内骨化的秩序。在这篇综述文章中，我们将介绍在理解转录因子在软骨内骨化中的作用和功能调节方面的最新进展。
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