[通过同时激活GABA(B)和NMDA受体加速恐惧记忆消退]

[Fear memory extinction accelerated by simultaneous activation of GABA(B) and NMDA receptors].

作者信息

Dubrovina N I

出版信息

Eksp Klin Farmakol. 2012;75(2):7-9.

Abstract

Effects of the N-methyl-D-aspartate (NMDA) agonist (D-cycloserine) and GABA(B) agonist (baclofen) on the fear memory extinction as manifested in the passive avoidance reaction in C57Bl/6J mice with "behavioral despair" (model of depression) and without previously developed stress have been studied. The positive acceleration of the fear memory extinction was observed in depressive mice upon the simultaneous administration of D-cycloserine and baclofen.

摘要

研究了N-甲基-D-天冬氨酸（NMDA）激动剂（D-环丝氨酸）和γ-氨基丁酸B（GABA(B)）激动剂（巴氯芬）对C57Bl/6J小鼠被动回避反应中恐惧记忆消退的影响，这些小鼠具有“行为绝望”（抑郁症模型）且之前未经历过应激。在同时给予D-环丝氨酸和巴氯芬时，观察到抑郁小鼠的恐惧记忆消退有正向加速作用。