光声断层扫描和荧光分子断层扫描：基于吲哚菁绿的对比研究。
Photoacoustic tomography and fluorescence molecular tomography: a comparative study based on indocyanine green.
机构信息
Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
出版信息
Med Phys. 2012 May;39(5):2512-7. doi: 10.1118/1.3700401.
PURPOSE
Both photoacoustic tomography (PAT) and fluorescence molecular tomography (FMT) can be used for molecular imaging when contrast agents are administrated. The goal of this work is to comparatively evaluate the performance of reflection-mode PAT and FMT in common phantom when indocyanine green (ICG) was used as a contrast agent.
METHODS
Reflection-mode PAT and FMT systems were developed. Target embedded in a background phantom with different ICG concentration, size, and depth location was examined. Comparisons were made in terms of target morphology, spatial resolution, and sensitivity between the two modalities.
RESULTS
Phantom results showed that PAT and FMT gave different image morphology. PAT offered higher spatial resolution, while FMT provided higher sensitivity. Thus, improved target detection could be achieved by correlating the complementary information obtained from the two modalities.
CONCLUSIONS
The combination of high resolution PAT and high sensitivity FMT will provide a more complete range of pathology spectra for more reliable target detection, suggesting a potentially better diagnostic tool when this combination coupled with the administration of ICG as contrast agent is applied to clinical problems in the future.
目的
当造影剂被给予时，光声断层扫描（PAT）和荧光分子断层扫描（FMT）都可用于分子成像。本工作的目的是在使用吲哚菁绿（ICG）作为造影剂时，比较评估反射模式 PAT 和 FMT 在普通体模中的性能。
方法
开发了反射模式 PAT 和 FMT 系统。在具有不同 ICG 浓度、大小和深度位置的背景体模中检查了嵌入的目标。比较了两种模式在目标形态、空间分辨率和灵敏度方面的差异。
结果
体模结果表明，PAT 和 FMT 给出了不同的图像形态。PAT 提供了更高的空间分辨率，而 FMT 提供了更高的灵敏度。因此，通过相关两种模式获得的互补信息，可以实现目标检测的改善。
结论
高分辨率 PAT 和高灵敏度 FMT 的结合将为更可靠的目标检测提供更完整的病理学光谱范围，当这种组合与 ICG 作为造影剂联合应用于未来的临床问题时，这将是一种更有潜力的诊断工具。
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