Peninsula Collaboration for Health, Operational Research, and Development, University of Exeter, Exeter, Devon, UK
Diabetes Care. 2012 Aug;35(8):1663-8. doi: 10.2337/dc11-2282. Epub 2012 May 7.
In the U.K., people with diabetes are typically screened for retinopathy annually. However, diabetic retinopathy sometimes has a slow progression rate. We developed a simulation model to predict the likely impact of screening patients with type 2 diabetes, who have not been diagnosed with diabetic retinopathy, every 2 years rather than annually. We aimed to assess whether or not such a policy would increase the proportion of patients who developed retinopathy-mediated vision loss compared with the current policy, along with the potential cost savings that could be achieved.
We developed a model that simulates the progression of retinopathy in type 2 diabetic patients, and the screening of these patients, to predict rates of retinopathy-mediated vision loss. We populated the model with data obtained from a National Health Service Foundation Trust. We generated comparative 15-year forecasts to assess the differences between the current and proposed screening policies. RESULTS The simulation model predicts that implementing a 2-year screening interval for type 2 diabetic patients without evidence of diabetic retinopathy does not increase their risk of vision loss. Furthermore, we predict that this policy could reduce screening costs by ~25%.
Screening people with type 2 diabetes, who have not yet developed retinopathy, every 2 years, rather than annually, is a safe and cost-effective strategy. Our findings support those of other studies, and we therefore recommend a review of the current National Institute for Health and Clinical Excellence (NICE) guidelines for diabetic retinopathy screening implemented in the U.K.
在英国,通常每年对糖尿病患者进行视网膜病变筛查。然而,糖尿病视网膜病变的进展速度有时较慢。我们开发了一种模拟模型,以预测每两年而不是每年筛查尚未诊断出糖尿病视网膜病变的 2 型糖尿病患者的可能影响。我们旨在评估这种政策是否会增加与当前政策相比发生视网膜病变导致视力丧失的患者比例,以及可能实现的潜在成本节约。
我们开发了一种模拟模型,模拟 2 型糖尿病患者视网膜病变的进展以及对这些患者的筛查,以预测视网膜病变导致视力丧失的发生率。我们使用从国民保健服务基金会信托基金获得的数据来填充模型。我们生成了 15 年的比较预测,以评估当前和拟议筛查政策之间的差异。
模拟模型预测,对尚无糖尿病视网膜病变证据的 2 型糖尿病患者实施每 2 年一次的筛查间隔不会增加他们视力丧失的风险。此外,我们预测该政策可以将筛查成本降低约 25%。
对尚未发生视网膜病变的 2 型糖尿病患者每两年而不是每年进行筛查是一种安全且具有成本效益的策略。我们的研究结果支持其他研究的结果,因此我们建议对英国实施的国民保健服务糖尿病视网膜病变筛查的现行国家卫生与临床优化研究所(NICE)指南进行审查。