Tayyebi-Khosroshahi Hamid, Houshyar Jalil, Dehgan-Hesari Reza, Alikhah Hosein, Vatankhah Amir-Mansour, Safaeian Abdol-Rasoul, Zonouz Neda Razzagi
Department of Internal Medicine, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Saudi J Kidney Dis Transpl. 2012 May;23(3):500-6.
C-reactive protein (CRP), a strong independent risk marker of cardiovascular disease (CVD), and tumor necrosis factor-alfa (TNF-α), a known pro-inflammatory cytokine, are elevated and have damaging effects in patients with chronic renal failure (CRF). Omega-3 fatty acids play an important modulatory role in inflammatory responses. The aim of this study is to review the alterations in serum levels of TNF-α, CRP and other parameters caused by omega-3 supplementation in dialysis patients. The clinical trial was performed in 37 patients with end-stage renal disease undergoing dialysis in hemodialysis centers of three university hospitals in Tabriz. Blood samples were obtained from the study patients for hemoglobin, albumin, ferritin, triglyceride, total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol, TNF-α and high specific-CRP (hs-CRP) measurement. The patients received 3 g omega-3 per day for 2 months. The side-effects noticed were nausea, diarrhea and dyspepsia and undesired drug smell. The difference noted in hemoglobin, albumin, ferritin, CRP, triglyceride, total, LDL and HDL-cholesterol before and after supplementation with omega-3 fatty acid was not statistically significant (P > 0.05). However, the use of omega-3 decreased the serum levels of TNF-α significantly. We conclude that the use of 3 g of omega-3 per day caused significant decrease in serum levels of TNF-α in the dialysis population, and its use is recommended in such patients.
C反应蛋白（CRP）是心血管疾病（CVD）的一个强有力的独立风险标志物，而肿瘤坏死因子-α（TNF-α）是一种已知的促炎细胞因子，在慢性肾衰竭（CRF）患者中水平升高且具有损害作用。ω-3脂肪酸在炎症反应中发挥重要的调节作用。本研究的目的是回顾ω-3补充剂对透析患者血清TNF-α、CRP及其他参数水平的影响。该临床试验在大不里士三所大学医院血液透析中心的37例终末期肾病透析患者中进行。采集研究患者的血样以检测血红蛋白、白蛋白、铁蛋白、甘油三酯、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇、TNF-α和高敏C反应蛋白（hs-CRP）。患者每天服用3克ω-3，持续2个月。观察到的副作用有恶心、腹泻、消化不良和药物异味。补充ω-3脂肪酸前后，血红蛋白、白蛋白、铁蛋白、CRP、甘油三酯、总胆固醇、LDL和HDL胆固醇的差异无统计学意义（P>0.05）。然而，ω-3的使用显著降低了血清TNF-α水平。我们得出结论，每天使用3克ω-3可使透析人群的血清TNF-α水平显著降低，建议此类患者使用。
