Department of Medicine I, Center of Oncology and Hematology, Wilhelminenspital, Vienna, Austria.
Oncologist. 2012;17(5):592-606. doi: 10.1634/theoncologist.2011-0391. Epub 2012 May 9.
The management of multiple myeloma has undergone profound changes over the recent past as a result of advances in our understanding of the disease biology as well as improvements in treatment and supportive care strategies. Notably, recent years have seen a surge in studies incorporating the novel agents thalidomide, bortezomib, and lenalidomide into treatment for different disease stages and across different patient groups. This article presents an update to a previous review of European treatment practices and is based on discussions during an expert meeting that was convened to review novel agent data published or presented at medical meetings until the end of 2011 and to assess their impact on treatment strategies.
近年来,由于我们对疾病生物学的理解不断深入,以及治疗和支持性护理策略的改进,多发性骨髓瘤的治疗发生了深刻的变化。值得注意的是,近年来,越来越多的研究将新型药物沙利度胺、硼替佐米和来那度胺纳入不同疾病阶段和不同患者群体的治疗中。本文是对之前一篇关于欧洲治疗实践的综述的更新,其基础是在一次专家会议上的讨论,该会议旨在回顾截至 2011 年底在医学会议上公布或展示的新型药物数据,并评估其对治疗策略的影响。