WAIS-R富尔德剖面图在HIV-1感染中的发生率。

Incidence of the WAIS-R Fuld profile in HIV-1 infection.

作者信息

van Gorp W G, Tulin S J, Evans G, Satz P

机构信息

West Los Angeles VA Medical Center, Neuropsychology Laboratory, CA 90073.

出版信息

J Clin Exp Neuropsychol. 1990 Oct;12(5):807-11. doi: 10.1080/01688639008401021.

DOI:10.1080/01688639008401021

PMID:2258439

Abstract

The incidence of a WAIS-R subtest "marker" sensitive to cholinergic dysfunction was assessed in a sample 116 homosexual males infected with HIV (Acquired Immunodeficiency Syndrome [AIDS] N = 40; AIDS Related Complex [ARC], N = 76). The incidence of positive profiles was low in the overall sample (11/116, 9%), and significantly lower than incidence rates reported for known cholinergic deficient groups (Alzheimer's disease; scopolamine). However, significantly more AIDS patients (8/40, 20%) than ARC patients (3/76, 4%) demonstrated positive profiles. These results suggest that, as a group, persons with ARC or AIDS do not show an increased incidence of the Fuld profile associated with cholinergic disruption, and offer continued support for diagnostic specificity of the Fuld formula for Alzheimer's disease.

摘要

在116名感染艾滋病毒的同性恋男性样本中（获得性免疫缺陷综合征[AIDS]患者40例；艾滋病相关综合征[ARC]患者76例），评估了对胆碱能功能障碍敏感的韦氏成人智力量表修订版（WAIS-R）子测验“指标”的发生率。总体样本中阳性结果的发生率较低（11/116，9%），且显著低于已知胆碱能缺乏组（阿尔茨海默病；东莨菪碱）报告的发生率。然而，艾滋病患者（8/40，20%）出现阳性结果的比例显著高于ARC患者（3/76，4%）。这些结果表明，作为一个群体，ARC或艾滋病患者并未表现出与胆碱能破坏相关的福尔兹量表结果发生率增加，这为福尔兹公式对阿尔茨海默病的诊断特异性提供了持续支持。