西伯利亚俄罗斯精神病住院患者的迟发性运动障碍中腺苷A2A受体未受累。
No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia.
作者信息
Ivanova Svetlana A, Al Hadithy Asmar F Y, Brazovskaya Natalia, Semke Arkadiy, Wilffert Bob, Fedorenko Olga, Brouwers Jacobus R B J, Loonen Anton J M
机构信息
Mental Health Research Institute SB RAMSci, Tomsk, Russian Federation.
出版信息
Hum Psychopharmacol. 2012 May;27(3):334-7. doi: 10.1002/hup.2226.
BACKGROUND
The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia.
METHODS
Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia.
RESULTS
Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype.
CONCLUSION
The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.
背景
腺苷A2A受体与纹状体多巴胺D2受体形成异源复合物。我们研究了腺苷A2A受体的一种特定多态性（2592 C/Tins）是否与迟发性运动障碍有关。
方法
对来自西伯利亚的146名白种人精神科住院患者进行了迟发性运动障碍的横断面评估。
结果
基因型或等位基因频率的组间比较无统计学显著差异。以迟发性运动障碍的发生为因变量的逻辑回归分析显示，与年龄、病程、性别和基因型无显著关联。
结论
A2A和D2受体之间的相互作用似乎不参与迟发性运动障碍的发生。
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