Institute for Maternal and Child Health, IRCCS "Burlo Garofolo" Trieste, Italy.
Epileptic Disord. 2012 Jun;14(2):174-80. doi: 10.1684/epd.2012.0507.
Involuntary movements can appear before and after initiation of vitamin B12 treatment. The pathogenesis of involuntary movements in vitamin B12 deficiency and their relationship with cobalamin injection remain unclear due to a lack of video-EEG documentation making the electroclinical correlation difficult to ascertain. Here, we report video-EEG and neuroimaging findings of an 11-month-old girl with vitamin B12 deficiency, who acutely developed involuntary movements a few days after initiation of vitamin B12 treatment with normal vitamin plasmatic levels. Abnormal movements were a combination of tremor and myoclonus involving the face, mouth, and left arm, which disappeared after discontinuation of therapy. [Published with video sequences].
在开始维生素 B12 治疗之前和之后,可能会出现不随意运动。由于缺乏视频脑电图记录,导致难以确定电临床相关性,因此维生素 B12 缺乏症中不随意运动的发病机制及其与钴胺素注射的关系尚不清楚。在这里,我们报告了一例 11 个月大的女孩维生素 B12 缺乏的视频脑电图和神经影像学发现,该女孩在开始维生素 B12 治疗几天后,在维生素血浆水平正常的情况下突然出现不随意运动。异常运动是面部、口腔和左臂的震颤和肌阵挛的组合,停药后消失。[随视频序列发布]。