Boonyarangkul Arthit, Leksakulchai Orawan
Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
J Med Assoc Thai. 2011 Dec;94 Suppl 7:S57-61.
To compare the level of pain between using manual vacuum aspiration and sharp curettage in the patients who had abnormal uterine bleeding that underwent uterine curettage under paracervical block with analgesics.
Randomized controlled trial study.
Between September 2009 to June 2010, 48 women with abnormal uterine bleeding who need to undergone uterine curettage were asked to join the present study and informed consents were signed. Twenty four women were randomly assigned into manual vacuum aspiration (MVA) group and other 24 women into sharp curettage group. The main outcome was the difference of the level of pain before, during and after procedure measured by using the visual analog scale and categorical pain scores. Fisher exact, Student t test and Mann-Whitney U test were used for statistical analysis.
The median visual analog score during MVA-procedure was significantly lower than the median visual analog score during in sharp curettage (median visual analog pain scores (interquartile range) 80 (30-100) vs. 45 (0-80); p < 0.01)). And the median score immediately after procedure in the MVA group was also significantly lower than in the sharp curettage group (median visual analog pain scores (interquartile range) 45 (0-80 vs. 25 (0-70); p = 0.02). The categorical pain score in the MVA group during procedure and immediately after procedure were also significantly lower than in the sharp curettage group. (No pain to mild pain vs. moderated to severe pain; p = 0.03, immediately after procedure: no pain to mild pain vs. moderated to severe pain; p = 0.01).
The level of pain in the patients who underwent uterine curettage by using MVA was lower than using sharp curettage. The using MVA may reduce pain compared to sharp curettage. However, more sample size research should be conducted to determine this significant.
比较在宫颈旁阻滞加用镇痛药下行刮宫术的异常子宫出血患者中,采用手动真空抽吸术和锐性刮宫术时的疼痛程度。
随机对照试验研究。
2009年9月至2010年6月期间,48例需要行刮宫术的异常子宫出血女性被邀请参加本研究并签署知情同意书。24名女性被随机分为手动真空抽吸术(MVA)组,另外24名女性分为锐性刮宫术组。主要结局是通过视觉模拟量表和分类疼痛评分测量的手术前、手术中和手术后疼痛程度的差异。采用Fisher精确检验、Student t检验和Mann-Whitney U检验进行统计分析。
MVA手术过程中的视觉模拟评分中位数显著低于锐性刮宫术中的视觉模拟评分中位数(视觉模拟疼痛评分中位数(四分位间距)80(30 - 100)对45(0 - 80);p < 0.01)。MVA组术后即刻的评分中位数也显著低于锐性刮宫术组(视觉模拟疼痛评分中位数(四分位间距)45(0 - 80)对25(0 - 70);p = 0.02)。MVA组手术过程中和术后即刻的分类疼痛评分也显著低于锐性刮宫术组。(手术过程中:无疼痛至轻度疼痛对中度至重度疼痛;p = 0.03,术后即刻:无疼痛至轻度疼痛对中度至重度疼痛;p = 0.01)。
采用MVA进行刮宫术的患者疼痛程度低于采用锐性刮宫术。与锐性刮宫术相比,使用MVA可能减轻疼痛。然而,需要进行更大样本量的研究来确定这一显著性。