泰国传统益智疗法及其草药成分的乙酰胆碱酯酶抑制活性。

Acetylcholinesterase inhibitory activity of Thai traditional nootropic remedy and its herbal ingredients.

作者信息

Tappayuthpijarn Pimolvan, Itharat Arunporn, Makchuchit Sunita

机构信息

Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumtani, Thailand.

出版信息

J Med Assoc Thai. 2011 Dec;94 Suppl 7:S183-9.

PMID:22619927

Abstract

The incidence of Alzheimer disease (AD) is increasing every year in accordance with the increasing of elderly population and could pose significant health problems in the future. The use of medicinal plants as an alternative prevention or even for a possible treatment of the AD is, therefore, becoming an interesting research issue. Acetylcholinesterase (AChE) inhibitors are well-known drugs commonly used in the treatment of AD. The aim of the present study was to screen for AChE inhibitory activity of the Thai traditional nootropic recipe and its herbal ingredients. The results showed that ethanolic extracts of four out of twenty-five herbs i.e. Stephania pierrei Diels. Kaempfera parviflora Wall. ex Baker, Stephania venosa (Blume) Spreng, Piper nigrum L at 0.1 mg/mL showed % AChE inhibition of 89, 64, 59, 50; the IC50 were 6, 21, 29, 30 microg/mL respectively. The other herbs as well as combination of the whole recipe had no synergistic inhibitory effect on AChE activity. However some plants revealed antioxidant activity. More research should have be performed on this local wisdom remedy to verify the uses in scientific term.

摘要

随着老年人口的增加，阿尔茨海默病（AD）的发病率逐年上升，未来可能会带来严重的健康问题。因此，使用药用植物作为AD的替代预防方法甚至可能的治疗方法正成为一个有趣的研究课题。乙酰胆碱酯酶（AChE）抑制剂是治疗AD常用的药物。本研究的目的是筛选泰国传统益智配方及其草药成分的AChE抑制活性。结果表明，25种草药中的4种乙醇提取物，即石蟾蜍、小花山柰、毛叶轮环藤、胡椒，在0.1mg/mL时对AChE的抑制率分别为89%、64%、59%、50%；IC50分别为6、21、29、30μg/mL。其他草药以及整个配方的组合对AChE活性没有协同抑制作用。然而，一些植物显示出抗氧化活性。应该对这种传统智慧疗法进行更多的研究，以从科学角度验证其用途。