Fiori Nastro Paolo, Schimmelmann Benno G, Gebhardt Eva, Monducci Elena, Resch Franz, Koch Eginhard, Schultze-Lutter Frauke
Dipartimento di Neurologia, Sapienza Universita di Roma.
Riv Psichiatr. 2012 Mar-Apr;47(2):116-25. doi: 10.1708/1069.11716.
The early detection and treatment of persons at-risk for psychosis is currently regarded a promising strategy in fighting the devastating consequences of psychotic disorders. The two current at-risk approaches, i.e., the "ultra high risk" and the "basic symptom" criteria, were mainly developed on adult samples. Initial evidence suggests, however, that they cannot simply be applied to children and adolescents. For ultra high risk criteria, there is indication of some attenuated psychotic symptoms being potentially non-specific in adolescents and of brief limited intermittent symptoms being difficult to clinically classify in children when observable behavioral correlates are missing. For basic symptoms, too, only preliminary indication of their usefulness in children and adolescents exists. Since developmental peculiarities in the assessment of basic symptoms should be considered, a child and youth version of the Schizophrenia Proneness Instrument (SPI-CY) was developed. In conclusion, research on the clinical-prognostic validity of the at-risk criteria and their potential adoption to the special needs of children and adolescents is needed. If a Prodromal Risk Syndrome for Psychosis or Attenuated Psychotic Symptoms Syndrome will be included into DSM-V, it has to be highlighted that its suitability for children and adolescents is only insufficiently known.
目前,对精神病高危人群的早期发现和治疗被视为对抗精神障碍毁灭性后果的一项有前景的策略。当前两种高危标准方法,即“超高危”和“基本症状”标准,主要是基于成人样本制定的。然而,初步证据表明,它们不能简单地应用于儿童和青少年。就超高危标准而言,有迹象表明,一些精神病性症状的减弱在青少年中可能是非特异性的,而当缺乏可观察到的行为关联时,短暂有限的间歇性症状在儿童中难以进行临床分类。对于基本症状,目前也仅有其在儿童和青少年中有用性的初步迹象。由于在评估基本症状时应考虑发育特点,因此开发了儿童青少年版的精神分裂症易感性量表(SPI-CY)。总之,需要对高危标准的临床预后有效性及其针对儿童和青少年特殊需求的潜在适用性进行研究。如果精神病前驱风险综合征或精神病性症状减弱综合征将被纳入《精神疾病诊断与统计手册》第五版(DSM-V),必须强调的是,其对儿童和青少年的适用性目前还了解不足。