Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
J Dermatolog Treat. 2013 Oct;24(5):377-86. doi: 10.3109/09546634.2012.699179. Epub 2012 Jul 25.
Comparative trials of benzoyl peroxide (BPO) have yielded contradictory results on its effectiveness for acne vulgaris. The aim of the study was to synthesise the evidence for the effectiveness of BPO-containing topical products for facial acne vulgaris.
Systematic review.
The Cochrane Central Register of Controlled trials, Cochrane Library, MEDLINE and other relevant databases were searched without publication date or language restriction.
We identified 22 trials involving 2212 participants; 12 trials compared BPO as single agent while the other 10 trials compared BPO in combination products. All trials reported lesion count as the outcome measure but only five trials provided numerical data. However, pooling of data from these trials was inappropriate due to variations between trials in terms of acne severity, comparator used and trial duration. Overall the study quality was fair but most studies had some bias particularly in method of random generation and allocation concealment. Although the results provide some evidence that BPO reduces acne-lesion count, the available evidence is not robust enough for firm conclusions.
There is no high quality evidence that topical BPO improves facial acne vulgaris, and further research is needed.
过氧化苯甲酰（BPO）的对照试验在其治疗寻常痤疮的疗效方面得出了相互矛盾的结果。本研究旨在综合评估含过氧化苯甲酰的局部产品治疗面部寻常痤疮的疗效证据。
系统评价。
我们无时间和语言限制地检索了 Cochrane 对照试验中央注册库、Cochrane 图书馆、MEDLINE 和其他相关数据库。
我们共确定了 22 项试验，涉及 2212 名参与者；12 项试验比较了 BPO 作为单一药物的疗效，而另外 10 项试验比较了 BPO 在联合产品中的疗效。所有试验均以皮损计数作为结局指标进行报告，但仅有 5 项试验提供了数值数据。然而，由于试验之间在痤疮严重程度、对照药物和试验持续时间方面存在差异，因此对这些试验的数据进行汇总是不合适的。总体而言，研究质量为中等，但大多数研究都存在一定的偏倚，特别是在随机分组和分配隐藏方法方面。尽管结果提供了一些证据表明 BPO 可减少痤疮皮损数量，但现有证据还不够充分，无法得出明确的结论。
目前尚无高质量证据表明局部用 BPO 可改善面部寻常痤疮，需要进一步研究。
Zotero 插件