[喉癌中的意义表达及其与内皮素-1、基质金属蛋白酶-9的关系]
[Significance expression and relationships with endothelin-1, matrix metalloproteinase-9 in the laryngeal carcinoma].
作者信息
Lin Yan, Zhang Jingjing, Liu Shixi, Liu Feng, Zou Jian, Zheng Mingxiu
机构信息
Department of Otorhinolaryngology, the Second Affiliated.Hospital of Kunming Medical College, Kunming, 650101, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Mar;26(6):245-7, 251.
OBJECTIVE
To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9 (MMP-9) in laryngeal carcinoma and their correlations with clinical features.
METHOD
The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.
RESULT
The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues (P < 0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-land MMP-9 correlated significantly with each other (r(s) = 0.693, P < 0.05).
CONCLUSION
The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
目的
评估内皮素-1（ET-1）和基质金属蛋白酶-9（MMP-9）在喉癌中的表达及其与临床特征的相关性。
方法
采用免疫组织化学方法检测58例喉癌标本、28例声带息肉标本和19例正常喉组织标本中ET-1和MMP-9的表达。
结果
与声带息肉和正常喉组织相比，喉癌中ET-1、MMP-9的表达明显更高（P < 0.05）。ET-1、MMP-9的表达与临床分期、T分期及淋巴结转移相关。ET-1和MMP-9的表达水平彼此显著相关（r(s)=0.693，P < 0.05）。
结论
ET-1和MMP-9的表达可能是喉癌的重要指标。
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