Bucher John R
Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Toxicol Pathol. 2013 Jan;41(1):125-7. doi: 10.1177/0192623312450632. Epub 2012 Jun 12.
Tox21 is a transformative effort on the part of several U.S. Federal agencies (the National Toxicology Program/National Institute of Environmental Health Sciences [NTP], the National Institutes of Health (NIH) Chemical Genomics Center/National Human Genome Research Institute [NCGC; now called the NIH Center for Translational Therapeutics, National Center for Advancing Translational Sciences] the Environmental Protection Agency's (EPA) National Center for Computational Toxicology, and recently the Food and Drug Administration) that are partnering to fundamentally change the science of safety toxicology. These agencies bring a comprehensive suite of capabilities and are working diligently together to develop, evaluate, and ultimately implement a new safety assessment paradigm. Toxicologic pathology has an important ongoing role in establishing the validity of this transformation, and may ultimately benefit as a discipline through an enhanced understanding of chemically induced disease mechanisms.
Tox21是美国几个联邦机构（国家毒理学计划/国家环境卫生科学研究所 [NTP]、美国国立卫生研究院 [NIH] 化学基因组学中心/国家人类基因组研究所 [NCGC；现称为NIH转化治疗中心，国家推进转化科学中心]、环境保护局 [EPA] 国家计算毒理学中心，以及最近的食品药品监督管理局）的一项变革性举措，这些机构正在合作从根本上改变安全毒理学科学。这些机构拥有一套全面的能力，并正在共同努力开发、评估并最终实施一种新的安全评估范式。毒理病理学在确立这一变革的有效性方面发挥着重要的持续作用，并且作为一门学科，最终可能会因对化学诱导疾病机制的深入理解而受益。
