吡拉西坦用于分娩时胎儿窘迫。
Piracetam for fetal distress in labour.
作者信息
Hofmeyr G Justus, Kulier Regina
机构信息
Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of FortHare, Eastern Cape Department of Health, East London, South Africa.
出版信息
Cochrane Database Syst Rev. 2012 Jun 13;2012(6):CD001064. doi: 10.1002/14651858.CD001064.pub2.
BACKGROUND
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress.
OBJECTIVES
The objective of this review was to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and perinatal morbidity.
SEARCH METHODS
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (15 February 2012).
SELECTION CRITERIA
Randomised trials of piracetam compared with placebo or no treatment for suspected fetal distress in labour.
DATA COLLECTION AND ANALYSIS
Both review authors assessed eligibility and trial quality.
MAIN RESULTS
One study of 96 women was included. Piracetam compared with placebo was associated with a trend to reduced need for caesarean section (risk ratio 0.57, 95% confidence interval 0.32 to 1.03). There were no statistically significant differences between the piracetam and placebo group for neonatal morbidity (measured by neonatal respiratory distress) or Apgar score.
AUTHORS' CONCLUSIONS: There is not enough evidence to evaluate the use of piracetam for fetal distress in labour.
背景
人们认为吡拉西坦可在脑细胞缺氧时促进其新陈代谢。它已被用于预防胎儿窘迫的不良影响。
目的
本综述的目的是评估吡拉西坦用于分娩时疑似胎儿窘迫对分娩方式和围产期发病率的影响。
检索方法
我们检索了Cochrane妊娠与分娩组试验注册库（2012年2月15日）。
选择标准
吡拉西坦与安慰剂或未治疗用于分娩时疑似胎儿窘迫的随机试验。
数据收集与分析
两位综述作者评估了研究的合格性和试验质量。
主要结果
纳入了一项涉及96名女性的研究。与安慰剂相比，吡拉西坦有降低剖宫产需求的趋势（风险比0.57，95%置信区间0.32至1.03）。在新生儿发病率（通过新生儿呼吸窘迫衡量）或阿氏评分方面，吡拉西坦组与安慰剂组之间无统计学显著差异。
作者结论
没有足够的证据来评估吡拉西坦用于分娩时胎儿窘迫的情况。
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