阻断脂质体和纳米管形成是含多价脂质的双组分膜的普遍现象。
Block Liposome and Nanotube Formation is a General Phenomenon of Two-Component Membranes Containing Multivalent Lipids.
作者信息
Zidovska Alexandra, Ewert Kai K, Quispe Joel, Carragher Bridget, Potter Clinton S, Safinya Cyrus R
机构信息
Materials, Physics, and Molecular, Cellular and Developmental Biology Departments, University of California at Santa Barbara, Santa Barbara, CA 93106.
出版信息
Soft Matter. 2011 Jan 1;7(18):8363-8369. doi: 10.1039/C1SM05481C. Epub 2011 Jun 20.
Abstract
We report a study on the formation of block liposomes (BLs) and nanotubes from membranes comprised of mixtures of membrane curvature-stabilizing multivalent cationic lipids MVL3(3+) and MVL5(5+) with neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). In conjunction with prior work on MVLBG2(16+), our experiments suggest that BL and nanotube formation is a general phenomenon in membranes containing multivalent lipids, thus enhancing the relevance of BLs for applications such as gene/drug storage and delivery or templating.
摘要
我们报告了一项关于由膜曲率稳定多价阳离子脂质MVL3(3+)和MVL5(5+)与中性1,2 - 二油酰 - sn - 甘油 - 3 - 磷脂酰胆碱（DOPC）的混合物组成的膜形成块状脂质体（BLs）和纳米管的研究。结合之前关于MVLBG2(16+)的工作，我们的实验表明，BL和纳米管的形成是含有多价脂质的膜中的普遍现象，从而增强了BLs在基因/药物储存与递送或模板等应用中的相关性。
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