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[肺转移瘤切除术:适应证与技术]

[Pulmonary metastasectomy: indication and technique].

作者信息

Osei-Agyemang T, Ploenes T, Passlick B

机构信息

Universitätsklinikum Freiburg, Thoraxchirurgie, Freiburg, Deutschland.

出版信息

Zentralbl Chir. 2012 Jun;137(3):234-41. doi: 10.1055/s-0031-1283958. Epub 2012 Jun 18.

Abstract

Distant metastases of solid tumours are most frequently located in the lung. Most patients with lung metastases suffer from multiple pulmonary lesions or metastases in other organs, which makes these patients unsuitable for surgical treatment. However, several studies suggest a survival benefit if complete resection of all pulmonary metastases is possible. In some patients pulmonary metastasectomy may even be the only curative treatment option. If pulmonary metastases are suspected contrast-enhanced computed tomography is the diagnostic procedure of first choice. Generally accepted rules for intended curative pulmonary metastasectomy are control of the primary tumour, technically completely resectable metastases, the exclusion of extrapulmonary metastases except for potentially completely resectable hepatic metastases and a functional operability. The most important prognostic factors are complete resection, the exact entity of the tumour, disease-free interval and, to a limited extent, also the number of metastases. In bilateral disease sternotomy and sequentially staged or one-stage thoracotomy are the standard surgical approaches to be considered, whereby thoracotomy is more advantageous in cases of centrally located lesions and left lower lobe metastases. In unilateral disease, video-assisted resection may be considered under certain circumstances. Primary aim must be R0 resection. Tissue-sparing pulmonary dissection techniques are proposed besides anatomic resections. In particular in cases of centrally located or multiple lesions an extensive expertise in thoracic surgery is necessary to preserve as much functional lung parenchyma as possible. Secondary mediastinal lymph node involvement is associated with an adverse prognosis and should therefore be ruled out preoperatively.

摘要

实体瘤的远处转移最常发生在肺部。大多数肺转移患者伴有多个肺部病变或其他器官转移,这使得这些患者不适合手术治疗。然而,多项研究表明,如果能够完全切除所有肺转移灶,则可能带来生存获益。在一些患者中,肺转移瘤切除术甚至可能是唯一的治愈性治疗选择。如果怀疑有肺转移,增强计算机断层扫描是首选的诊断方法。预期治愈性肺转移瘤切除术的普遍接受规则包括原发肿瘤得到控制、转移灶在技术上可完全切除、除潜在可完全切除的肝转移外排除肺外转移以及具备功能可操作性。最重要的预后因素是完全切除、肿瘤的确切类型、无病间期以及在一定程度上转移灶的数量。对于双侧病变,胸骨切开术以及分期或一期开胸手术是应考虑的标准手术方法,其中开胸手术在中央型病变和左下叶转移的情况下更具优势。对于单侧病变,在某些情况下可考虑电视辅助切除术。首要目标必须是R0切除。除了解剖性切除外,还提出了保留组织的肺解剖技术。特别是在中央型或多发病变的情况下,需要胸外科的广泛专业知识以尽可能保留更多有功能的肺实质。纵隔淋巴结转移与不良预后相关,因此应在术前排除。

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