钯催化的使用近化学计量一氧化碳的双重羰基化反应：方便获得取代的 13C2 标记的苯乙胺。
Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: expedient access to substituted 13C2-labeled phenethylamines.
机构信息
Department of Chemistry, Center for Insoluble Protein Structures (InSPIN), and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
出版信息
J Org Chem. 2012 Jul 20;77(14):6155-65. doi: 10.1021/jo3009337. Epub 2012 Jul 11.
A novel and general approach for (13)C(2)- and (2)H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.
一种新颖而通用的方法被开发出来，用于（13）C（2）-和（2）H-标记的苯乙胺衍生物，该方法基于碳骨架的高度汇聚的单步组装。通过钯催化的芳基碘与近化学计量的一氧化碳的双羰基化反应，高效地将两个碳-13 同位素掺入苯乙胺中。
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