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[双相情感障碍的早期识别与干预:研究现状与展望]

[Early recognition and intervention for bipolar disorders: state of research and perspectives].

作者信息

Pfennig A, Correll C U, Leopold K, Juckel G, Bauer M

机构信息

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Deutschland.

出版信息

Nervenarzt. 2012 Jul;83(7):897-902. doi: 10.1007/s00115-012-3589-3.

Abstract

Early signs of developing bipolar disorder are frequently already present in adolescence or early adulthood. Despite this the disorder is often diagnosed late leading to a delay in adequate treatment. Benefiting from the experience of the early recognition of psychosis, we aimed to strengthen synergies by founding a German-speaking network of scientists in the fields of bipolar disorders and early recognition of mental disorders ("Network for Early Recognition and Intervention in Bipolar Disorders", short: NERIBID) in order to develop joint scientific and clinical standards and design and conduct collaborative study projects. Initial key aspects of establishing the network included a review of the research to date and the (further) development of instruments for early recognition. Preliminary results of these initiatives are presented in this article. In the long term it has to be clarified whether early detection of at-risk states for the development of bipolar disorders is possible and, if so, which early intervention strategies are most appropriate? If it is possible to reliably identify individuals at true risk for bipolar disorder, the next question to be answered is how early detection initiatives that presently are mostly realized within research projects could be established pragmatically within clinical settings in the health care system.

摘要

双相情感障碍的早期迹象在青少年期或成年早期往往就已出现。尽管如此,该疾病常常诊断较晚,导致适当治疗延迟。借鉴早期识别精神病的经验,我们旨在通过建立一个由双相情感障碍领域和精神障碍早期识别领域的德语科学家组成的网络(“双相情感障碍早期识别与干预网络”,简称:NERIBID)来加强协同作用,以制定联合科学和临床标准,并设计和开展合作研究项目。建立该网络的初步关键方面包括对迄今为止的研究进行综述以及(进一步)开发早期识别工具。本文介绍了这些举措的初步结果。从长远来看,必须明确是否有可能早期发现双相情感障碍发病的高危状态,如果可以,哪种早期干预策略最合适?如果能够可靠地识别真正有双相情感障碍风险的个体,接下来要回答的问题是,目前大多在研究项目中实现的早期检测举措如何能在医疗保健系统的临床环境中切实建立起来。

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