基于氧化氧铵阳离子的可逆荧光探针的开发用于活细胞中亚溴酸的检测。
Development of reversible fluorescence probes based on redox oxoammonium cation for hypobromous acid detection in living cells.
机构信息
State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, CAS, P. R. China.
出版信息
Chem Commun (Camb). 2012 Aug 11;48(62):7735-7. doi: 10.1039/c2cc33264g. Epub 2012 Jun 27.
PMID:22735154
Abstract
We describe the synthesis, properties, and application of two reversible fluorescent probes, mCy-TemOH and Cy-TemOH, for HOBr sensing and imaging in live cells. The two probes contain a hydroxylamine functional group for the monitoring of HOBr oxidation/ascorbic acid reduction events. Confocal fluorescence microscopy has established the HOBr detection in live-cells.
摘要
我们描述了两种可逆荧光探针 mCy-TemOH 和 Cy-TemOH 的合成、性质和应用，用于活细胞中 HOBr 的传感和成像。这两种探针都含有一个羟胺官能团，用于监测 HOBr 的氧化/抗坏血酸还原事件。共聚焦荧光显微镜已经证实了活细胞中 HOBr 的检测。
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