Department of Internal Medicine, Inje University Haeundae Paik-Hospital, Inje University College of Medicine, 1435, Jwa-dong, Haeundae-gu, Busan, 612-030, Republic of Korea.
Int J Infect Dis. 2012 Sep;16(9):e669-72. doi: 10.1016/j.ijid.2012.05.1019. Epub 2012 Jun 26.
Trends in hepatitis B virus (HBV) infection are important in evaluating the effectiveness of the recommended routine vaccination of infants and adolescents.
The prevalence of HBV infection was determined in a representative sample of the Korea National Health and Nutrition Examination Survey for 1998 (n=9771) and 2009 (n=8304). Participants aged ≥10 years were tested for the hepatitis B surface antigen (HBsAg).
The overall age-adjusted HBsAg seroprevalence was 4.6% (95% confidence interval (CI) 4.2-5.0%) in 1998 and 3.2% (95% CI 2.9-3.6%) in 2009, which represents a relative decrease of 30.4% between the two survey populations (p<0.05). The prevalence of HBsAg decreased among persons 10-19 years of age (from 2.2% to 0.3%), 20-29 years of age (from 5.4% to 2.5%), 30-39 years of age (from 6.1% to 4.3%), 40-49 years of age (from 5.1% to 4.7%), and 50-59 years of age (from 5.3% to 3.7%). HBsAg seroprevalence did not decrease among persons ≥60 years of age (2.7% vs. 2.9%).
These data show a decline in HBsAg seroprevalence, primarily due to the dramatic decrease in adolescents and younger adults.
乙型肝炎病毒（HBV）感染趋势对于评估推荐的婴儿和青少年常规疫苗接种的效果非常重要。
在韩国国家健康和营养检查调查 1998 年（n=9771）和 2009 年（n=8304）的代表性样本中确定了 HBV 感染的流行率。≥10 岁的参与者接受了乙型肝炎表面抗原（HBsAg）检测。
1998 年和 2009 年，经过年龄调整的 HBsAg 血清阳性率分别为 4.6%（95%置信区间[CI] 4.2-5.0%）和 3.2%（95% CI 2.9-3.6%），这两个调查人群之间的相对下降了 30.4%（p<0.05）。10-19 岁人群（从 2.2%降至 0.3%）、20-29 岁人群（从 5.4%降至 2.5%）、30-39 岁人群（从 6.1%降至 4.3%）、40-49 岁人群（从 5.1%降至 4.7%）和 50-59 岁人群（从 5.3%降至 3.7%）的 HBsAg 阳性率下降。≥60 岁人群的 HBsAg 血清阳性率没有下降（2.7%比 2.9%）。
这些数据表明 HBsAg 血清阳性率下降，主要是由于青少年和年轻成年人急剧减少。
