通过原位激光诱导合成尖端增强拉曼光谱探针对生物纳米材料的近场拉曼光谱研究。

Near-field Raman spectroscopy of biological nanomaterials by in situ laser-induced synthesis of tip-enhanced Raman spectroscopy tips.

机构信息

School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

出版信息

Opt Lett. 2012 Jun 15;37(12):2256-8. doi: 10.1364/OL.37.002256.

DOI:10.1364/OL.37.002256

Abstract

We report a new approach in tip-enhanced Raman spectroscopy (TERS) in which TERS-active tips with enhancement factors of ∼10(-5)× can be rapidly (1-3 min) produced in situ by laser-induced synthesis of silver nanoparticles at the tip apex. The technique minimizes the risks of tip contamination and damage during handling and provides in situ feedback control, which allows the prediction of the tip performance. We show that TERS tips produced by this technique enable the measurement of spatially resolved TERS spectra of self-assembled peptide nanotubes with a spatial resolution of ∼20 nm.

摘要

我们报告了一种新的尖端增强拉曼光谱（TERS）方法，通过在尖端处激光诱导合成银纳米粒子，可以快速（1-3 分钟）原位生成增强因子约为 10(-5)×的 TERS 活性尖端。该技术最大限度地降低了处理过程中尖端污染和损坏的风险，并提供了原位反馈控制，从而可以预测尖端性能。我们表明，通过该技术制备的 TERS 尖端能够测量自组装肽纳米管的空间分辨 TERS 光谱，空间分辨率约为 20nm。