Walach N, Guterman A, Zaidman J L, Scharf S, Weinberger L, Kaufman S
Department of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel.
Neoplasma. 1990;37(6):627-30.
Leukocyte alkaline phosphatase (LAP) scores and carcinoembryonic antigen (CEA) levels were analyzed in 53 patients suffering from breast cancer. All patients underwent mastectomy and received adjuvant treatment, and all lived more than 5 years after diagnosis without metastatic disease. Thirty-three patients received adjuvant radiotherapy, and 20 patients received adjuvant chemotherapy. The median LAP score before radiotherapy was 117 +/- 48; two months after the beginning of radiotherapy this value was 175 +/- 71, being significantly higher than the original value (p less than 0.001), and one year after the beginning of radiotherapy it was 105 +/- 63, which approximated the normal scores. The median LAP score before chemotherapy was 138 +/- 69; two months after the beginning of chemotherapy it was 194 +/- 63, i.e. significantly higher than before chemotherapy (p less than 0.002), and one year after the beginning of chemotherapy it was 150 +/- 56. Median CEA levels before radiotherapy were 6.4 +/- 5.1 ng/ml; two months after the beginning of radiotherapy this value was 6.0 +/- 5.0 ng/ml; and one year later 7.4 +/- 6.2 ng/ml. Median CEA levels before chemotherapy were 8.1 +/- 12.0 ng/ml; two months after the beginning of chemotherapy 12.6 +/- 13.0 ng/ml (p less than 0.05) in comparison with the values before chemotherapy; and one year after the beginning of chemotherapy it was 8.6 +/- 5.4 ng/ml. We concluded that the LAP scores were influenced by adjuvant radio- or chemotherapy, and the CEA levels were influenced by chemotherapy.
对53例乳腺癌患者的白细胞碱性磷酸酶（LAP）评分和癌胚抗原（CEA）水平进行了分析。所有患者均接受了乳房切除术并接受辅助治疗，且所有患者在诊断后存活超过5年，无转移性疾病。33例患者接受辅助放疗，20例患者接受辅助化疗。放疗前LAP评分中位数为117±48；放疗开始后两个月，该值为175±71，显著高于初始值（p<0.001），放疗开始后一年为105±63，接近正常评分。化疗前LAP评分中位数为138±69；化疗开始后两个月为194±63，即显著高于化疗前（p<0.002），化疗开始后一年为150±56。放疗前CEA水平中位数为6.4±5.1 ng/ml；放疗开始后两个月该值为6.0±5.0 ng/ml；一年后为7.4±6.2 ng/ml。化疗前CEA水平中位数为8.1±12.0 ng/ml；化疗开始后两个月为12.6±13.0 ng/ml（与化疗前值相比，p<0.05）；化疗开始后一年为8.6±5.4 ng/ml。我们得出结论，LAP评分受辅助放疗或化疗的影响，CEA水平受化疗的影响。
