EP4：纤维化谜题的新片段。
EP4: a new piece in the fibrotic puzzle.
出版信息
Kidney Int. 2012 Jul;82(2):132-5. doi: 10.1038/ki.2012.125.
PMID:22743564
Abstract
Most progressive and severe acute kidney diseases lead to renal fibrosis, for which we still lack effective treatment options. Prostaglandin E(2) (PGE(2)) is one of the most abundant prostanoids, exerting its pleiotropic functions via four receptors, EP(1) through EP(4). Recent studies indicate that the PGE(2)-EP(4) pathway is a potent endogenous renoprotective system that limits renal fibrosis by acting on multiple cellular targets.
摘要
大多数进行性和严重的急性肾脏疾病会导致肾纤维化，对此我们仍然缺乏有效的治疗方法。前列腺素 E2（PGE2）是最丰富的前列烷之一，通过四个受体 EP1 到 EP4 发挥其多效性功能。最近的研究表明，PGE2-EP4 途径是一种强大的内源性肾保护系统，通过作用于多个细胞靶点来限制肾纤维化。
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