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聚乙二醇化促红细胞生成素用于肾脏病领域贫血的治疗。

Peginesatide for the treatment of anemia in the nephrology setting.

作者信息

Graul A I

机构信息

Thomson Reuters, Barcelona, Spain.

出版信息

Drugs Today (Barc). 2012 Jun;48(6):395-403. doi: 10.1358/dot.2012.48.6.1825620.

Abstract

Anemia is a major complication in patients with chronic kidney disease, as the damaged kidney is unable to produce enough erythropoietin. Peginesatide (formerly known as Hematide™) is a synthetic, peptide-based erythropoiesis-stimulating agent linked to polyethylene glycol. Based on extensive preclinical and clinical data substantiating the efficacy and safety of this agent, it was approved in the U.S. in March 2012 for the treatment of anemia due to chronic kidney disease in adult patients on dialysis. Peginesatide (Omontys®) was launched in the U.S. in April 2012.

摘要

贫血是慢性肾病患者的主要并发症,因为受损的肾脏无法产生足够的促红细胞生成素。聚乙二醇化促红细胞生成素(曾用名Hematide™)是一种与聚乙二醇相连的合成肽类促红细胞生成刺激剂。基于大量证实该药物有效性和安全性的临床前及临床数据,它于2012年3月在美国获批,用于治疗接受透析的成年慢性肾病患者的贫血。聚乙二醇化促红细胞生成素(Omontys®)于2012年4月在美国上市。

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