Hall-Edwards Radiotherapy Research Group, University Hospital Birmingham NHS Foundation Trust, United Kingdom, B15 2TH.
Med Phys. 2012 Jun;39(6):3262-9. doi: 10.1118/1.4709601.
A linac delivering intensity-modulated radiotherapy (IMRT) can benefit from a flattening filter free (FFF) design which offers higher dose rates and reduced accelerator head scatter than for conventional (flattened) delivery. This reduction in scatter simplifies beam modeling, and combining a Monte Carlo dose engine with a FFF accelerator could potentially increase dose calculation accuracy. The objective of this work was to model a FFF machine using an adapted version of a previously published virtual source model (VSM) for Monte Carlo calculations and to verify its accuracy.
An Elekta Synergy linear accelerator operating at 6 MV has been modified to enable irradiation both with and without the flattening filter (FF). The VSM has been incorporated into a commercially available treatment planning system (Monaco™ v 3.1) as VSM 1.6. Dosimetric data were measured to commission the treatment planning system (TPS) and the VSM adapted to account for the lack of angular differential absorption and general beam hardening. The model was then tested using standard water phantom measurements and also by creating IMRT plans for a range of clinical cases.
The results show that the VSM implementation handles the FFF beams very well, with an uncertainty between measurement and calculation of <1% which is comparable to conventional flattened beams. All IMRT beams passed standard quality assurance tests with >95% of all points passing gamma analysis (γ < 1) using a 3%/3 mm tolerance.
The virtual source model for flattened beams was successfully adapted to a flattening filter free beam production. Water phantom and patient specific QA measurements show excellent results, and comparisons of IMRT plans generated in conventional and FFF mode are underway to assess dosimetric uncertainties and possible improvements in dose calculation and delivery.
能够提供比传统(平坦化)传输更高剂量率和减少加速器头散射的调强放疗(IMRT)直线加速器可以从无均整过滤器(FFF)设计中受益。这种散射的减少简化了束流建模,并且将蒙特卡罗剂量引擎与 FFF 加速器相结合可能会提高剂量计算的准确性。这项工作的目的是使用先前发表的虚拟源模型(VSM)的改编版本对 FFF 机器进行建模,以验证其准确性。
对 Elekta Synergy 直线加速器进行了修改,使其能够在带有和不带有均整过滤器(FF)的情况下进行照射。VSM 已被整合到商业上可用的治疗计划系统(Monaco™ v 3.1)中,作为 VSM 1.6。为了委托治疗计划系统(TPS)并适应缺乏角度微分吸收和一般束硬化的情况,对剂量学数据进行了测量。然后使用标准水模测量和创建一系列临床病例的 IMRT 计划来测试该模型。
结果表明,VSM 实现非常好地处理了 FFF 束,测量值与计算值之间的不确定性<1%,与传统的平坦化束相当。所有 IMRT 束都通过了标准质量保证测试,使用 3%/3mm 容差,超过 95%的所有点通过伽马分析(γ<1)。
成功地将平坦化束的虚拟源模型改编为无均整过滤器自由束产生。水模和患者特定的 QA 测量显示出优异的结果,正在进行常规和 FFF 模式下生成的 IMRT 计划的比较,以评估剂量不确定性和剂量计算和交付方面的可能改进。