Mineo Chieko, Shaul Philip W
Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Drug Discov Today Dis Mech. 2011 Summer;8(1-2):e47-e52. doi: 10.1016/j.ddmec.2011.12.002.
Antiphospholipid syndrome is an autoimmune disease characterized by the presence of circulating antiphospholipid antibodies (aPL) that promote thrombosis, pregnancy complications and cardiovascular diseases. Alterations in the function of vascular cells induced by aPL underlie these outcomes. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.
抗磷脂综合征是一种自身免疫性疾病,其特征是循环中存在抗磷脂抗体(aPL),这些抗体可促进血栓形成、妊娠并发症和心血管疾病。aPL诱导的血管细胞功能改变是这些结果的基础。本综述将讨论最近的研究发现,这些发现表明了一种新机制,即aPL拮抗内皮细胞产生一氧化氮,从而促进血栓形成。