与半胱胺和泛硫乙胺相关的中枢神经系统的临床前和临床研究。

Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system.

Vécsei L, Widerlöv E

Department of Psychiatry and Neurochemistry, University of Lund, Sweden.

Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):835-62. doi: 10.1016/0278-5846(90)90072-o.

Abstract

Cysteamine is formed by degradation of coenzyme A (CoA) and causes somatostatin (SS), prolactin and noradrenaline depletion in the brain and peripheral tissues. 2. Cysteamine influences several behavioral processes, like active and passive avoidance behavior, open-field activity, kindled seizures, pain perception and SS-induced barrel rotation. 3. Cysteamine has several established (cystinosis, radioprotection, acetaminophen poisoning) and theoretical (Huntington's disease, prolactin-secreting adenomas) indications in clinical practice. 4. Pantethine is a naturally occurring compound which is metabolized to cysteamine. 5. Pantethine depletes SS, prolactin and noradrenaline with lower efficacy compared to that of cysteamine. 6. Pantethine is well tolerated by patients and has been suggested to treatment of atherosclerosis. The other possible clinical indications (alcoholism, Parkinson's disease, instead of cysteamine) are discussed.

摘要

半胱胺由辅酶A（CoA）降解形成，可导致大脑和外周组织中生长抑素（SS）、催乳素和去甲肾上腺素耗竭。2. 半胱胺影响多种行为过程，如主动和被动回避行为、旷场活动、点燃性癫痫、痛觉以及SS诱导的躯体旋转。3. 半胱胺在临床实践中有多种已确定的（胱氨酸病、辐射防护、对乙酰氨基酚中毒）和理论上的（亨廷顿舞蹈病、催乳素分泌性腺瘤）适应症。4. 泛硫乙胺是一种天然存在的化合物，可代谢为半胱胺。5. 与半胱胺相比，泛硫乙胺耗竭SS、催乳素和去甲肾上腺素的效力较低。6. 患者对泛硫乙胺耐受性良好，有人建议用其治疗动脉粥样硬化。还讨论了其他可能的临床适应症（酒精中毒、帕金森病，可替代半胱胺）。