Kanamori Masahiko, Suzuki Kayo, Yasuda Taketoshi, Hori Takeshi
Department of Human Science 1, University of Toyama, Toyama City, Toyama 930-0194, Japan.
Oncol Lett. 2012 Jun;3(6):1213-1215. doi: 10.3892/ol.2012.641. Epub 2012 Mar 9.
In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with positivities of CD99, vimentin and bcl-2. Cytogenetically, all 20 analyzed cells showed the clonal aberrations add(1)(q23), t(1;16)(p21;p11.2), inv(5)(q11.2;q15). This finding adds to the new karyotype spectrum of CD99-positive soft tissue sarcomas.
在本研究中,我们报告了一名31岁男性大腿CD99阳性软组织肉瘤的细胞遗传学分析,该肿瘤发生了1号和16号染色体之间罕见的易位以及5号染色体倒位,并已转移至肺部。组织学上,肿瘤表现为卵圆形或短梭形的非典型细胞,CD99、波形蛋白和bcl-2呈阳性。细胞遗传学分析显示,所有20个分析细胞均呈现克隆性畸变add(1)(q23)、t(1;16)(p21;p11.2)、inv(5)(q11.2;q15)。这一发现丰富了CD99阳性软组织肉瘤的新核型谱。