膳食钙导致甲状腺的细胞学和生物化学变化。

Dietary calcium induced cytological and biochemical changes in thyroid.

机构信息

Endocrinology & Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, Kolkata, West Bengal, India.

出版信息

Environ Toxicol Pharmacol. 2012 Sep;34(2):454-465. doi: 10.1016/j.etap.2012.06.003. Epub 2012 Jun 26.

DOI:10.1016/j.etap.2012.06.003

PMID:22789468

Abstract

Certain epidemiological studies revealed correlation between hard water consumption (with high calcium) and thyroid size of the population, though the possible alterations in thyroid physiology upon calcium exposure are still inconclusive. Adult male Wistar strain rats were subjected to calcium treatment at the doses of 0.5g%, 1.0g% and 1.5g% calcium chloride (CaCl(2)) for 60 days. The parameters studied were - thyroid gland weight, histopathology, histomorphometry; thyroid peroxidase (TPO), 5'-deiodinase I (DI), sodium-potassium adenosine triphosphatase (Na(+)-K(+)-ATPase) activities; serum total and free thyroxine (tT4, fT4), total and free triiodothyronine (tT3, fT3), thyroid stimulating hormone (TSH) levels. Enlargement of thyroid with hypertrophic and hyperplastic changes, retarded TPO and 5'-DI but enhanced Na(+)-K(+)-ATPase activities, augmented serum total and free T4 and TSH but decreased total and free T3 levels and low T3/T4 ratio (T3:T4) were observed in the treated groups. All these findings indicate development of goitrogenesis upon exposure to excessive dietary calcium.

摘要

某些流行病学研究表明，硬水（高钙）的摄入与人群的甲状腺大小之间存在相关性，尽管钙暴露对甲状腺生理的可能改变仍不确定。雄性 Wistar 大鼠连续 60 天接受 0.5%、1.0%和 1.5%氯化钙（CaCl2）剂量的钙处理。研究的参数包括 - 甲状腺重量、组织病理学、组织形态计量学；甲状腺过氧化物酶（TPO）、5'-脱碘酶 I（DI）、钠钾三磷酸腺苷酶（Na(+)-K(+)-ATPase）活性；血清总甲状腺素（tT4，fT4）、总游离三碘甲状腺原氨酸（tT3，fT3）、促甲状腺激素（TSH）水平。在处理组中观察到甲状腺肿大伴有肥大和增生变化、TPO 和 5'-DI 延迟但 Na(+)-K(+)-ATPase 活性增强、血清总甲状腺素（tT4，fT4）和 TSH 增加但总甲状腺素（tT3，fT3）和游离三碘甲状腺原氨酸（tT3，fT3）水平降低，以及低三碘甲状腺原氨酸/甲状腺素（T3：T4）比值。所有这些发现表明，暴露于过量膳食钙会导致致甲状腺肿发生。