科伊巴辛 A-D，具有有趣生物合成起源的抗利什曼海生蓝细菌聚酮化合物。
Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA.
出版信息
Org Lett. 2012 Aug 3;14(15):3878-81. doi: 10.1021/ol301607q. Epub 2012 Jul 13.
Abstract
Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the "beta branch" forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.
摘要
四种不饱和聚酮内酯衍生物，即 coibacins A-D，从巴拿马海洋蓝藻 cf. Oscillatoria sp. 中分离得到。在这些共存代谢物中观察到两种不同类型的末端，一种是类似于 curacin A 中的甲基环丙基环，另一种是类似于 jamaicamides 中的甲基乙烯基氯，这表明“β 分支”形成生物合成过程具有令人着迷的灵活性。coibacins 具有选择性抗利什曼原虫活性和强大的抗炎活性。
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