Laboratory of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima, Kagoshima 890-0065, Japan.
Vet J. 2013 Feb;195(2):260-1. doi: 10.1016/j.tvjl.2012.06.014. Epub 2012 Jul 12.
Trapped neutrophil syndrome is an autosomal recessive inherited neutropenia in Border collies. The causative mutation is a 4base pair deletion in exon 19 of the canine VPS13B gene. In this study, a real-time PCR assay was developed and a genotyping survey was carried out in Border collies in Japan. The carrier frequency was 11.1%, suggesting that the mutant allele frequency is high enough to warrant measures to control and prevent the disease.
中性粒细胞捕获综合征是一种在边境牧羊犬中发生的常染色体隐性遗传性中性粒细胞减少症。致病突变是犬 VPS13B 基因外显子 19 中的 4 碱基对缺失。本研究中，建立了实时 PCR 检测方法，并对日本边境牧羊犬进行了基因分型调查。携带者频率为 11.1%，表明突变等位基因频率足够高，需要采取措施来控制和预防该疾病。
Zotero 插件