皮肤恶性黑素瘤的放射治疗。
Radiation therapy for cutaneous melanoma.
机构信息
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Dermatol Clin. 2012 Jul;30(3):525-33. doi: 10.1016/j.det.2012.04.011. Epub 2012 Jun 7.
Abstract
Radiation therapy is used infrequently for cutaneous melanoma, despite research suggesting benefit in certain clinical scenarios. This review presents data forming the highest level of evidence supporting the use of radiation therapy. Retrospective and prospective studies demonstrate radiation therapy for primary tumors is associated with high control rates. Two randomized trials have found improvements in regional control with adjuvant radiotherapy to regional lymphatics. Retrospective and prospective studies demonstrate radiation therapy is associated with palliative response and metastatic tumor control. Optimal care of melanoma patients involves radiation therapy; awareness of this is incumbent of clinicians caring for patients with this disease.
摘要
尽管有研究表明在某些临床情况下放疗有益，但放疗在皮肤黑色素瘤中的应用并不常见。本综述介绍了支持放疗应用的最高级别证据数据。回顾性和前瞻性研究表明，放疗原发性肿瘤可获得较高的局部控制率。两项随机试验发现，辅助放疗区域淋巴结可提高区域控制率。回顾性和前瞻性研究表明，放疗与姑息反应和转移性肿瘤控制相关。为黑色素瘤患者提供最佳治疗需要放疗；关注这一点是照顾此类疾病患者的临床医生的责任。
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