双相情感障碍中锂敏感性与糖原合成酶激酶3β基因多态性之间的关联

[Association between lithium sensitivity and GSK3beta gene polymorphisms in bipolar disorder].

作者信息

Numajiri Maki, Aoki Jun, Iwahashi Kazuhiko, Fukamauchi Fumihiko, Enomoto Minoru, Yoshihara Eiji, Murayama Ohshi, Nishizawa Daisuke, Ikeda Kazutaka, Ishigooka Jun

机构信息

Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara 252-5201, Japan.

出版信息

Nihon Shinkei Seishin Yakurigaku Zasshi. 2012 Jun;32(3):161-3.

PMID:22834106

Abstract

GSK-3beta codes for an enzyme which is a target for the action of mood stabilizers, lithium and possibly of valproic acid. The relationship between the polymorphisms (SNPs) of GSK-3beta-50T/C and -1727A/T and the effect of lithium was studied among 29 Japanese bipolar patients. It was shown that GSK-3beta-50T/C may be linked with the effect of lithium treatment. There is a significantly higher T-allele frequency in the lithium responders than non-responders (df = 1, chi2 = 6.971, 0.01 > P > 0.001; Yates' continuity correction). However, there is not a significant relationship between the polymorphisms of GSK-3beta-1727A/T and the effect of lithium treatment.

摘要

GSK - 3β编码一种酶，该酶是心境稳定剂锂以及可能还有丙戊酸作用的靶点。在29名日本双相情感障碍患者中研究了GSK - 3β - 50T/C和 - 1727A/T的多态性（单核苷酸多态性，SNPs）与锂效应之间的关系。结果表明，GSK - 3β - 50T/C可能与锂治疗的效果有关。锂反应者中的T等位基因频率显著高于无反应者（自由度 = 1，卡方 = 6.971，0.01 > P > 0.001；采用耶茨连续性校正）。然而，GSK - 3β - 1727A/T的多态性与锂治疗效果之间没有显著关系。