[应激对完整和去卵巢雌性大鼠中氟哌啶醇诱导的僵住症及其昼夜节律的影响]
[Stress effect on haloperidol-induced catalepsy and its circadian rhythm in intact and ovariectomized female rats].
作者信息
Baturin V A, Manvelian É A, Bulgakova M D
出版信息
Eksp Klin Farmakol. 2012;75(5):3-6.
PMID:22834120
Abstract
Stressing reduces the intensity of haloperidol-induced catalepsy in intact female rats and increases it in ovariectomized animals. Ovarioectomy reduces the severity of haloperidol catalepsy. Circadian rhythm acrophase of the cataleptogenic haloperidol activity in female rats after ovariectomy and stress exhibits significant displacement.
摘要
应激可降低完整雌性大鼠中氟哌啶醇诱导的僵住症强度，而在去卵巢动物中则会增强。去卵巢会减轻氟哌啶醇诱导的僵住症严重程度。去卵巢和应激后，雌性大鼠中诱导僵住症的氟哌啶醇活性的昼夜节律峰相位出现显著位移。
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