促动力蛋白 2 在实验性精索静脉曲张大鼠睾丸中的潜在作用。
Potential role of prokineticin 2 in experimental varicocele-induced rat testes.
机构信息
Institute of Family Planning Research, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Urology. 2012 Oct;80(4):952.e15-9. doi: 10.1016/j.urology.2012.05.033. Epub 2012 Jul 26.
OBJECTIVE
To determine the possible role of prokineticin 2 in varicocele by inducing varicoceles in adult rats.
METHODS
Forty male Sprague-Dawley rats were used for sham operation (n = 10) and varicocele (n = 30) groups. Experimental varicocele was induced by partial ligation of the left renal vein in the varicocele, whereas the sham operation group only received a sham induction of varicocele. Left testes were harvested for real-time quantitative polymerase chair readtion analysis 2, 4, and 8 weeks after the induction of varicocele.
RESULTS
The expression of prokineticin 2 mRNA in 8-week varicocele-induced rats was significantly higher (P < .05) than that in the sham operation group.
CONCLUSION
The present study suggests that prokineticin 2 expression is increased by varicocele induction and it may have a role in varicocele-induced infertility.
目的
通过诱导成年大鼠精索静脉曲张来确定促血管生成素 2 在精索静脉曲张中的可能作用。
方法
40 只雄性 Sprague-Dawley 大鼠用于假手术（n = 10）和精索静脉曲张（n = 30）组。精索静脉曲张组通过左肾静脉部分结扎诱导实验性精索静脉曲张，而假手术组仅接受精索静脉曲张的假诱导。精索静脉曲张诱导后 2、4 和 8 周采集左侧睾丸进行实时定量聚合酶链反应分析。
结果
精索静脉曲张诱导 8 周后，促血管生成素 2 mRNA 的表达明显高于假手术组（P <.05）。
结论
本研究表明，促血管生成素 2 的表达在精索静脉曲张诱导后增加，它可能在精索静脉曲张引起的不育中起作用。
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