Exercise Physiology and Biochemistry Laboratory, Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, 62110 Serres, Greece.
Oxid Med Cell Longev. 2012;2012:628352. doi: 10.1155/2012/628352. Epub 2012 Jul 10.
This study investigates whether vitamin E can attenuate eccentric exercise-induced soleus muscle injury as indicated by the amelioration of in situ isometric force decline following a low-frequency fatigue protocol (stimulation at 4 Hz for 5 min) and the ability of the muscle to recover 3 min after the termination of the fatigue protocol. Adult male Wistar rats were divided into vitamin E-supplemented or placebo-supplemented groups studied at rest, immediately post-exercise or 48 h post-exercise. Daily dl-α-tocopheryl acetate intraperitoneal injections of 100 mg/kg body mass for 5 consecutive days prior to exercise doubled its plasma levels. Fatigue index and recovery index expressed as a percentage of the initial tension. FI at 0 h post- and 48 h post-exercise respectively was 88% ± 4.2% and 89% ± 6.8% in the vitamin E groups versus 76% ± 3% and 80% ± 11% in the placebo groups. RI was 99% ± 3.4% and 100% ± 6% in the vitamin E groups versus 82% ± 3.1% and 84% ± 5.9% in the placebo groups. Complementally to the traditionally recorded maximal force, low-frequency fatigue measures may be beneficial for assessing injury-induced decrease in muscle functionality.
本研究旨在探讨维生素 E 是否可以减轻离心运动引起的比目鱼肌损伤，其依据是低频疲劳方案（4 Hz 刺激 5 分钟）后原位等长力下降的改善情况，以及肌肉在疲劳方案结束后 3 分钟恢复的能力。成年雄性 Wistar 大鼠分为维生素 E 补充组和安慰剂补充组，分别在休息时、运动后即刻或运动后 48 小时进行研究。在运动前连续 5 天每天腹腔内注射 100mg/kg 体重的 dl-α-生育酚醋酸酯，可使其血浆水平增加一倍。疲劳指数和恢复指数分别表示为初始张力的百分比。运动后 0 小时和 48 小时的 FI 分别为维生素 E 组 88%±4.2%和 89%±6.8%，安慰剂组 76%±3%和 80%±11%。RI 分别为维生素 E 组 99%±3.4%和 100%±6%，安慰剂组 82%±3.1%和 84%±5.9%。除了传统记录的最大力外，低频疲劳测量可能有助于评估损伤引起的肌肉功能下降。
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