2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece.
Gynecol Endocrinol. 2013 Feb;29(2):125-8. doi: 10.3109/09513590.2012.708801. Epub 2012 Jul 31.
To assess the prevalence of climacteric symptoms and their association with demographic, life-style and hormonal parameters in Greek peri- and recently postmenopausal women.
1025 Greek women who were either perimenopausal or within their first 5 postmenopausal years participated in this cross-sectional observational study. Menopausal symptoms were assessed by the Greene Climacteric Scale and were tested for associations with demographic, anthropometric, life-style and hormonal parameters.
29.8% Of the women reported moderate to severe menopausal symptoms. More specifically, 39.2% reported vasomotor, 21.3% psychological, 6.3% psychosomatic and 34.5% sexual symptoms. Years since menopause (r = 0.13, p < 0.01), waist circumference (r = 0.11, p < 0.05) as well as serum FSH, LH and estradiol (r = 0.15, r = 0.118, r = -0.157; p < 0.01) correlated with the intensity of menopausal symptoms. In the multivariate analysis years since menopause and serum estradiol were the only significant predictors of menopausal symptoms (b = -0.158 and b = -0.198, p < 0.001, respectively), explaining though only 4.8% of the variance.
One out of three Greek women has moderate to severe climacteric symptoms during the menopause transition or the first postmenopausal years. This frequency is comparable to other White populations. Menopausal age and endogenous estrogens are significant predictors of climacteric symptoms.
评估希腊绝经前期和近期绝经后妇女绝经期症状的流行情况及其与人口统计学、生活方式和激素参数的关系。
本横断面观察性研究纳入了 1025 名希腊绝经前期或绝经后 5 年内的女性。采用 Greene 绝经症状量表评估绝经症状,并检测其与人口统计学、人体测量学、生活方式和激素参数的关系。
29.8%的女性报告有中度至重度绝经症状。具体而言,39.2%有血管舒缩症状,21.3%有心理症状,6.3%有躯体症状,34.5%有性功能障碍症状。绝经年限(r = 0.13,p < 0.01)、腰围(r = 0.11,p < 0.05)以及血清 FSH、LH 和雌二醇(r = 0.15,r = 0.118,r = -0.157;p < 0.01)与绝经症状的严重程度相关。多元分析显示,绝经年限和血清雌二醇是绝经症状的唯一显著预测因素(b = -0.158 和 b = -0.198,p < 0.001),但仅能解释 4.8%的方差。
三分之一的希腊女性在绝经过渡期或绝经后最初几年有中度至重度绝经期症状。这种频率与其他白种人群相当。绝经年龄和内源性雌激素是绝经症状的重要预测因素。