Zhang Xian-Tao, Jiao Hao-Yan, Suo Qi-Liang
Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China.
Zhong Yao Cai. 2012 Mar;35(3):430-3.
To study the pharmacokinetics of ginkgolide B for injection in rats.
The serum concentration of ginkgolide B was determined by LC-MS and calculate its parameter of pharmacokinetics via DAS2.0 software.
After intravenous of 0.75, 3.75 and 14.0 mg/kg ginkgolide B, parameters of pharmacokinetics of ginkgolide B were: Tmax were all (0.083 +/- 0) h, Cmax were (422.312 +/- 14.203), (1608.467 +/- 226.677), (1987.036 +/- 237.202) microg/L, AUC0-1 were (533.833 +/- 114.943), (1786.029 +/- 137.066), (1943.44 +/- 415.892) microg x h/L.
Ginkgolide B has three compartment model in rats.
研究注射用银杏内酯B在大鼠体内的药代动力学。
采用液相色谱-质谱联用法测定银杏内酯B的血清浓度，并通过DAS2.0软件计算其药代动力学参数。
静脉注射0.75、3.75和14.0mg/kg银杏内酯B后，银杏内酯B的药代动力学参数为：Tmax均为(0.083±0)h，Cmax分别为(422.312±14.203)、(1608.467±226.677)、(1987.036±237.202)μg/L，AUC0-1分别为(533.833±114.943)、(1786.029±137.066)、(1943.44±415.892)μg·h/L。
银杏内酯B在大鼠体内呈三室模型。
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