Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India.
Anal Chim Acta. 2012 Sep 19;743:33-40. doi: 10.1016/j.aca.2012.06.053. Epub 2012 Jul 13.
A promising and highly sensitive voltammetric method has been developed for the first time for the determination of epinephrine (EP) and 5-hydroxytryptamine (5-HT) using 120 MeV Ag ion irradiated multi-walled carbon nano tube (MWCNT) based sensor. The MWCNT were irradiated at various fluences of 1e12, 3e12 and 1e13 ions cm(-2) using palletron accelerator. The simultaneous determination of EP and 5-HT has been carried out in phosphate buffer solution of pH 7.20 using square wave voltammetry and cyclic voltammetry. Experimental results suggested that irradiation of MWCNT by Ag ions enhanced the electrocatalytic activity due to increase in effective surface area and insertion of Ag ions, leading to a remarkable enhancement in peak currents and shift of peak potentials to less positive values as compared to the unirradiated MWCNT (pristine). The developed sensor exhibited a linear relationship between peak current and concentration of EP and 5-HT in the range 0.1-105 μM with detection limit (3σ/b) of 2 nM and 0.75 nM, respectively. The practical utility of irradiation based MWCNT sensor has been demonstrated for the determination of EP and 5-HT in human urine and blood samples.
首次开发了一种有前途且高灵敏度的伏安法，用于使用 120 MeV Ag 离子辐照的多壁碳纳米管（MWCNT）基传感器测定肾上腺素（EP）和 5-羟色胺（5-HT）。MWCNT 在 palletron 加速器上以 1e12、3e12 和 1e13 离子 cm（-2）的各种通量进行辐照。在 pH 7.20 的磷酸盐缓冲溶液中使用方波伏安法和循环伏安法同时测定 EP 和 5-HT。实验结果表明，由于有效表面积的增加和 Ag 离子的插入，Ag 离子辐照 MWCNT 增强了电催化活性，导致峰电流显着增强，峰电位向更正的方向移动与未辐照的 MWCNT（原始）相比。与未辐照的 MWCNT（原始）相比，所开发的传感器在 0.1-105 μM 的范围内表现出与 EP 和 5-HT 浓度之间的线性关系，检测限（3σ/b）分别为 2 nM 和 0.75 nM。辐照 MWCNT 传感器的实际应用已在人尿和血液样本中测定 EP 和 5-HT 中得到证明。
Zotero 插件