Chiriac Anca Mirela, Demoly Pascal
Hôpital Arnaud-de-Villeneuve, département de pneumologie et addictologie, Inserm U657, 34295 Montpellier cedex 5, France.
Presse Med. 2013 Apr;42(4 Pt 1):395-404. doi: 10.1016/j.lpm.2012.06.005. Epub 2012 Aug 9.
Respiratory allergies represent a global and public health problem, due to their prevalence (still increasing), morbidity, impact on the quality of life and costs for the society. They mainly concern rhinitis (or rhinoconjunctivitis) and asthma. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options that are otherwise not appropriate, such as allergen immunotherapy and allergen avoidance, that are prescribed following a stepwise approach. It has been a century since the first trial in specific immunotherapy was performed and this still remains the only disease modifying treatment for allergic individuals. In terms of route of administration, sublingual immunotherapy represents a good alternative to subcutaneous immunotherapy, considering its proven efficacy and better safety profile.
呼吸道过敏是一个全球性的公共卫生问题,这是由于其患病率(仍在上升)、发病率、对生活质量的影响以及给社会带来的成本。它们主要涉及鼻炎(或鼻结膜炎)和哮喘。过敏的诊断取决于接触过敏原时的症状史以及过敏原特异性IgE的检测。准确诊断过敏可开启其他情况下不适用的治疗选择,例如过敏原免疫疗法和避免接触过敏原,这些治疗是按照逐步治疗方法来开具的。自首次进行特异性免疫疗法试验以来已有一个世纪,而这仍然是针对过敏个体的唯一疾病改善疗法。就给药途径而言,考虑到其已证实的疗效和更好的安全性,舌下免疫疗法是皮下免疫疗法的一个很好的替代选择。