Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clin Cancer Res. 2012 Aug 15;18(16):4257-65. doi: 10.1158/1078-0432.CCR-12-0315.
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
胰腺癌是由特定癌症相关基因的遗传和获得性突变引起的。在胰腺癌中最常见的遗传改变的发现为从正常细胞到非浸润性前体病变,最终到广泛转移疾病的进展的基本途径提供了深入的了解。此外,最近的遗传发现为开发基于基因的方法提供了新的机会,用于早期检测、个性化治疗和胰腺肿瘤的分子分类。