1-硫杂-4b-氮杂环戊[b]芴-4,10-二酮的合成及抗真菌活性。
Synthesis and antifungal activity of 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones.
机构信息
College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-ku, Seoul 120-750, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5777-9. doi: 10.1016/j.bmcl.2012.07.097. Epub 2012 Aug 5.
PMID:22902652
Abstract
1-Thia-4b-aza-cyclopenta[b]fluorene-4,10-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1-thia-4b-aza-cyclopenta[b]fluorene-4,10-diones would be antifungal agents.
摘要
噻吩并[4b]氮杂环戊二烯-4,10-二酮类化合物被合成并测试了其对两种致病真菌菌株的体外抗真菌活性。在所测试的化合物中，许多化合物表现出良好的抗真菌活性。结果表明，1-噻吩并[4b]氮杂环戊二烯-4,10-二酮类化合物可能是抗真菌剂。
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