CD209-336A/G 和-871A/G 多态性与结核病易感性的关联：一项荟萃分析。
Association between CD209 -336A/G and -871A/G polymorphisms and susceptibility of tuberculosis: a meta-analysis.
机构信息
Department of Laboratory Medicine, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
出版信息
PLoS One. 2012;7(7):e41519. doi: 10.1371/journal.pone.0041519. Epub 2012 Jul 24.
BACKGROUND
The association between CD209 promoter polymorphisms (-336A/G, -871A/G) and tuberculosis (TB) risk has been widely reported, but results of previous studies remain controversial and ambiguous. To assess the association between CD209 polymorphisms and TB risk, a meta-analysis was performed.
METHODS
Based on comprehensive searches of the PubMed, Embase, Web of Science, Weipu, and CBM databases, we identified outcome data from all articles estimating the association between CD209 polymorphisms and TB risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated.
RESULTS
A total of 14 studies with 3,610 cases and 3,539 controls were identified. There was no significant association between CD209 -336A/G polymorphism and TB risk (OR = 1.04, 95% CI = 0.91-1.19 for G vs. A; OR = 1.13, 95% CI = 0.84-1.53 for GG vs. AA; OR = 1.04, 95% CI = 0.87-1.24 for GG+AG vs. AA; OR = 1.11, 95% CI = 0.88-1.39 for GG vs. AG+AA). However, the significant association was revealed for Asians in GG vs. AA (OR = 2.48, 95% CI = 1.46-4.22, P = 0.0008) and GG vs. AG+AA (OR = 2.10, 95% CI = 1.33-3.32, P = 0.001). For the CD209 -871A/G polymorphism, lack of an association was also found (OR = 0.81, 95% CI = 0.70-0.95 for G vs. A; OR = 1.00, 95% CI = 0.52-1.93 for GG vs. AA; OR = 0.73, 95% CI = 0.60-0.89 for GG+AG vs. AA; OR = 1.09, 95% CI = 0.57-2.10 for GG vs. AG+AA).
CONCLUSION
The present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to TB susceptibility. However, the GG genotype of CD209 -336A/G polymorphism might be a genetic risk factor that increases TB susceptibility for Asians in GG vs. AA and GG vs. AG+AA.
背景
CD209 启动子多态性（-336A/G、-871A/G）与结核病（TB）风险之间的关联已被广泛报道，但先前的研究结果仍存在争议和不明确。为了评估 CD209 多态性与 TB 风险之间的关联，进行了荟萃分析。
方法
基于对 PubMed、Embase、Web of Science、维普和 CBM 数据库的全面搜索，我们从所有估计 CD209 多态性与 TB 风险之间关联的文章中确定了结局数据。使用 95%置信区间（CI）计算合并的优势比（OR）。
结果
共纳入 14 项研究，包括 3610 例病例和 3539 例对照。CD209-336A/G 多态性与 TB 风险之间无显著关联（G 对 A 的 OR=1.04，95%CI=0.91-1.19；GG 对 AA 的 OR=1.13，95%CI=0.84-1.53；GG+AG 对 AA 的 OR=1.04，95%CI=0.87-1.24；GG 对 AG+AA 的 OR=1.11，95%CI=0.88-1.39）。然而，在亚洲人群中发现 GG 对 AA（OR=2.48，95%CI=1.46-4.22，P=0.0008）和 GG 对 AG+AA（OR=2.10，95%CI=1.33-3.32，P=0.001）的关联具有统计学意义。对于 CD209-871A/G 多态性，也未发现关联（G 对 A 的 OR=0.81，95%CI=0.70-0.95；GG 对 AA 的 OR=1.00，95%CI=0.52-1.93；GG+AG 对 AA 的 OR=0.73，95%CI=0.60-0.89；GG 对 AG+AA 的 OR=1.09，95%CI=0.57-2.10）。
结论
本荟萃分析表明，CD209 启动子多态性（-336A/G、-871A/G）不太可能对 TB 易感性产生实质性影响。然而，CD209-336A/G 多态性的 GG 基因型可能是一个遗传风险因素，使亚洲人群中 GG 对 AA 和 GG 对 AG+AA 的 TB 易感性增加。
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