State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9226-37. doi: 10.1002/anie.201200859. Epub 2012 Aug 28.
Often used as a common solvent for chemical reations and utilized widely in industry as a reagent, N,N-dimethylformamide (DMF) has played an important role in organic synthesis for a long time. Numerous highly useful articles and reviews discussing its utilizations have been published. With a focus on the performance of DMF as a multipurpose precursor for various units in numerous reactions, this Minireview summarizes recent developments in the employment of DMF in the fields of formylation, aminocarbonylation, amination, amidation, and cyanation, as well as its reaction with arynes.
N,N-二甲基甲酰胺（DMF）常被用作化学反应的通用溶剂，在工业中广泛用作试剂，在有机合成中长期发挥着重要作用。已经发表了许多讨论其利用的非常有用的文章和评论。本文重点介绍了 DMF 作为多种反应中各种单元的多功能前体的性能，综述了 DMF 在甲酰化、氨甲酰化、氨基化、酰胺化和氰化领域的应用以及与芳基炔反应的最新进展。
