The Walton Centre NHS Foundation Trust, Liverpool, UK.
Mult Scler. 2013 Apr;19(4):475-9. doi: 10.1177/1352458512457720. Epub 2012 Aug 30.
Neuropathic pruritus (itch) is an uncommon, but well described, symptom in neurology. There are itch-specific neurons in the dorsal horn of the spinal cord. We noted excessive pruritus in patients with neuromyelitis optica (NMO).
We aimed to explore the characteristics of pruritus in NMO patients.
We reviewed case records of a well-defined cohort of 45 serial aquaporin-4 antibody-positive patients visiting the national NMO service. All patients were interviewed.
Of the 45 antibody-positive NMO patients, 44 had myelitis and 12 of those 44 (27.3%) patients reported pruritus within a week of other symptoms of transverse myelitis with central cord involvement. In three patients, pruritus was the first symptom of a relapse, while in one case, pruritus was the very first symptom of the index episode of NMO.
Neuropathic pruritus seems to be a common, but under-recognised symptom of myelitis associated with NMO.
神经性瘙痒（瘙痒）是神经病学中一种不常见但描述明确的症状。脊髓背角中有瘙痒特异性神经元。我们注意到视神经脊髓炎（NMO）患者存在过度瘙痒。
我们旨在探讨 NMO 患者瘙痒的特征。
我们回顾了在全国性 NMO 服务机构就诊的 45 例连续水通道蛋白-4 抗体阳性患者的明确队列的病例记录。对所有患者进行了访谈。
在 45 例抗水通道蛋白-4 抗体阳性的 NMO 患者中，44 例有脊髓炎，其中 12 例（27.3%）在横断性脊髓炎伴中央索受累的其他症状出现一周内出现瘙痒。在 3 例患者中，瘙痒是复发的首发症状，而在 1 例患者中，瘙痒是 NMO 首发发作的首发症状。
神经性瘙痒似乎是一种常见但未被认识的与 NMO 相关的脊髓炎症状。
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