Dipartimento di Scienze ed Innovazione Tecnologica, Università del Piemonte Orientale, Alessandria, Italy.
Planta Med. 2012 Oct;78(15):1639-44. doi: 10.1055/s-0032-1315149. Epub 2012 Aug 30.
Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20 µM.
两种新的糖基化和酰化类黄酮，即槲皮素-3-O-[(6-咖啡酰基)-β-吡喃葡萄糖基 (1 → 3) α-鼠李吡喃糖苷]-7-O-α-鼠李吡喃糖苷（2）和山柰酚-3-O-[(6-咖啡酰基)-β-吡喃葡萄糖基 (1 → 3) α-鼠李吡喃糖苷]-7-O-α-鼠李吡喃糖苷（3），与已知的槲皮素-3-O-甲基醚（1）一起，从凤尾蕨属植物 Ophioglossum vulgatum L 的地上部分分离得到。它们的结构通过 1D 和 2D NMR 光谱、ESI-MS 和 ESI-HRMS 光谱确定。发现化合物 1-3 均在角质形成细胞划痕愈合试验中具有活性，其中 3 是最活跃的化合物，在 20 μM 时表现出最大活性。
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