三例甲状腺乳头状癌和一例甲状腺滤泡性腺瘤的细胞遗传学分析。
Cytogenetic analyses of three papillary carcinomas and a follicular adenoma of the thyroid.
作者信息
Olah E, Balogh E, Bojan F, Juhasz F, Stenszky V, Farid N R
机构信息
Department of Pediatrics, Medical University, Debrecen, Hungary.
出版信息
Cancer Genet Cytogenet. 1990 Jan;44(1):119-29. doi: 10.1016/0165-4608(90)90204-n.
Cytogenetic data of three papillary carcinomas and a follicular adenoma using direct preparations or cell cultures or both after 7 to 60 days in vitro are presented. Although karyotype of the follicular adenoma proved completely normal, in each of the three papillary carcinomas a modal chromosome number in the diploid range and a deleted 11q were observed. In case 1 the del(11)(q23) was associated with rearrangement of chromosome 1 and other marker chromosomes. Our results suggest that 11q deletion may be specific for papillary carcinoma of the thyroid.
本文呈现了3例乳头状癌和1例滤泡性腺瘤在体外培养7至60天后，采用直接制片法、细胞培养法或两种方法并用所获得的细胞遗传学数据。尽管滤泡性腺瘤的核型完全正常，但在3例乳头状癌中均观察到二倍体范围内的众数染色体数及11号染色体长臂缺失。在病例1中，del(11)(q23)与1号染色体重排及其他标记染色体相关。我们的结果提示，11号染色体长臂缺失可能是甲状腺乳头状癌的特异性表现。
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